Effects of environmental chemicals

The bioengineered liver developed in Padma Rajagopalan’s lab is a powerful and facile system to understand how chemicals released into the environment may harm humans. CTE students can expose the liver mimic to multiple chemicals and study responses of individual cell types at the phenotypic, transcriptomic, proteomic, and metabolomic level, e.g., in collaboration with Rich Helm. The students will have opportunities to collaborate with other CTE trainees, e.g., advised by T. M. Murali, Lenwood Heath, and John Tyson to analyze the dataset to determine chemicals induce similar responses in the liver. Thus, student can learn how to exploit bioengineered tissues to answer a question of societal importance.