Connecting top-down and bottom-up models of systems biology

Two distinct approaches are being used to study complex cellular systems. The first, top-down approach automatically analyzes large-scale datasets for correlations between genes and proteins... Read More

Research Opportunities

CTE students and faculty have the unique opportunity and the capability to realize the promise of fusing tissue engineering, computational science, and systems biology. CTE faculty have pioneered several fundamental technologies including layered tissue architectures (Rajagopalan), comprehensive and sensitive molecular profiling techniques (Helm), computational mining and modeling of massive datasets (Murali, Heath), dynamic models of cellular processes (Tyson), microfluidic systems (Davalos), toxicological systems (Ehrich), and animal models of disease (Prater). Our group includes a bioethicist (Zallen) who studies social, ethical, and policy issues arising from advances in genetic technologies.

The pages highlight some of the research projects that CTE scientists are involved in. Prospective students can also learn about new research opportunities that are available.

  • Microfluidic liver chips


    Drs. Rajagopalan and Davalos are seeking to build and culture a miniaturized version of the in vitro 3D liver mimic within a microfluidic chip. The microfluidic liver mimic will be a complete dynamic 3D liver model on chip that will enable metabolic...

  • Effects of environmental chemicals


    The bioengineered liver developed in Padma Rajagopalan’s lab is a powerful and facile system to understand how chemicals released into the environment may harm humans. CTE students can expose the liver mimic to multiple chemicals and study responses...

  • 3D Liver Mimics


    The liver is one of the important organs in our bodies, playing a vital role in glucose homeostasis, the synthesis of bile acids for the metabolism of cholesterol, and the secretion of proteins to aid clotting. The liver is also primarily responsible environmental...