Spotlight
Signaling hypergraphs
Signaling pathways function as information-passing mechanisms of the cell. A number of extensively manually curated databases maintain the current knowledge-base for signaling pathways,... Read More
Current Research Projects
CTE students and faculty have the unique opportunity and the capability to realize the promise of fusing tissue engineering, computational science, and systems biology. CTE faculty have pioneered several fundamental technologies including layered tissue architectures (Rajagopalan), comprehensive and sensitive molecular profiling techniques (Helm), computational mining and modeling of massive datasets (Murali, Heath), dynamic models of cellular processes (Tyson), microfluidic systems (Davalos), toxicological systems (Ehrich), and animal models of disease (Prater). Our group includes a bioethicist (Zallen) who studies social, ethical, and policy issues arising from advances in genetic technologies.
The pages highlight some of the research projects that CTE scientists are involved in. Prospective students can also learn about new research opportunities that are available.
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Electroporation for targeted ablation of tumors
CTE faculty members Drs. Verbridge and Davalos are currently working to understand cell-specific responses to High Frequency Irreversible Electroporation (HFIRE) pulses, in order to ultimately translate this technique for the targeted ablation of malignant...
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Signaling hypergraphs
Signaling pathways function as information-passing mechanisms of the cell. A number of extensively manually curated databases maintain the current knowledge-base for signaling pathways, inviting computational approaches for prediction and analysis...
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Connecting top-down and bottom-up models of systems biology
Two distinct approaches are being used to study complex cellular systems. The first, top-down approach automatically analyzes large-scale datasets for correlations between genes and proteins. However, it is often difficult to design experiments from these results. The...