A new integrated model of the yeast START transition

The cell cycle is the process through which cells duplicate their genetic material and divide. A collaborative publication between John Tyson, Jean Peccoud, and T. M. Murali in a special issue on Quantitative Biology of Molecular Biology of the Cell reports on an integrated computational and experimental effort to refine mathematical models of the cell cycle by experimentally testing the predictions of the model on novel combinations of mutants not studied previously in the literature.